Curriculum Vitae (Medical)

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Note to Twitter/X people: I had severe ME in which I was bedridden for 20 hours per day for 15 years (I am near normal at this writing, I work full-time and have projects on the side).  I went to 50 practitioners of various sorts from 3 top tier endocrinologists, GPs, CFS doctors, acupuncture, biofeedback, herbalists, homeopaths and everybody in between.

Some were helpful (minor ways) but most were dead ends. I wasted much time, money and the most precious commodity which is hope. Hope is vital for life; I don't need to tell you that. 

I started my intensive research after experiencing a major setback. I spent hundreds of hours in the Ohio State Medical Library, making countless phone calls to researchers and was able to uncover the reason behind the setback. I likely have over 30,000 hours in research that mainly centers around peer-reviewed research articles. 

Many research hours later, I devote a minimum of 2 hours per day in medical research that I am willing to share with anyone who needs help. I do not ask for anything in return. If you were to scale Mt. Everest, you would ask for a Sherpa who could tell you the pitfalls and how to avoid them, the same should hold true for difficult health challenges. What people think they know and what they truly know are oftentimes two different worlds. Purity of data is important and the ability to spot subtle clues is also important. 

ME/CFS and Long Covid (Vax Injury) are complex diseases that require a multi-layered approach. There has to be a sequence of therapies to make this work. 

My posts at PhoenixRising LINK CFS Forums

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Patrick Bayer
Curriculum vitae is a Latin word that simply means 'the course of my life', it is a compendium of knowledge and experiences that we accumulate in our lifetime.  For me that driving force has been my disease, in which I developed severe Myalgic Encephalomyelitis or ME.  This condition was sadly called chronic fatigue syndrome which is nothing more than a wastebasket diagnosis according to my friend.

 At age 24, I inherited the leadership role at our family business after the untimely death of my father. This event sent me deeper in CFS.

I had suffered with ME for most of my  life, by age 14 I began to exhibit clear signs of ME most likely due to one the many viruses that can be attributed to ME, of course viruses are not the only culprit in this condition.  I also believe that environmental toxins, Vitamin D and magnesium deficiencies and a parasitic worm infection contributed to the disease.


(my blog post on ME/CFS Etiology)

   

Cortisol is a powerful drug that your body uses to maintain homeostasis.  Homeostasis simply put is balance, in which the body uses a number of modulators to help the body stay in some sense of normalcy.   Cortisol is released under stressful conditions be it psychological in which it is most closely associated but cortisol is released under physical, mental or biological stress.  Biological stress is the least understood of the stressors and includes infections both acute and stealth infections which most ME patients have.  Biological stress also comes from inadequate nutrients such as magnesium and vitamin D but also from environmental toxins in which Americans are exposed to in various ways.  Mercury is a good example of this and for years it was perfectly acceptable to place mercury in your mouth, of course the ADA denied any wrongdoing and today the silver fillings have disappeared not based on toxicity problems but they are not "cosmetically pretty".

 Cortisol is a powerful drug that your body releases that serves a number of beneficial processes, unfortunately when cortisol is released continuously, it begins to have deleterious effects such as suppression of the immune system, changes neurological patterns etc.  It is known as a catabolic hormone in which catabolsm simply means to break down, so it breaks down proteins, fatty acids and other nutrients, it does this to prepare the body for the fight or flight syndrome.   It breaks downs those substances to fuel these stress responses.  As a side note, magnesium losses are significant with high cortisol and  magnesium is so closely associated with both the cardiovascular and immune responses.  This why people suffer from heart attacks and immune problems like cancer.  We blame it on stress when really we should blame it on lack of proper nutrition, particularly magnesium.

It was not the viruses or the cortisol that damaged me but rather I contracted a protozoa parasite that did incredible damage to me.  I developed Cushing's disease from the massive immune response, I became incredibly ill and as I tell my friend, "you don't know sick until you know parasite sick".   It was after contracting this that the wheels fell off.  Sadly, it was up to me to diagnose both the Cushing's and the parasite issue, and to add insult to injury, it was up to me to treat this parasite.

I found out the hard way that the medical system is woefully inadequate in solving these complex problems.  So in an effort to resolve my health crisis, I have been diligent in accumulating knowledge, I firmly believe that 'knowledge is power' and that knowledge saved my life and I have proven that by outliving Cushing's disease by some 15 years.   Medical literature points that Cushing's patients typically have short lifespans following diagnosis - most say 5 years is all you get.   The reason is simply in that Cushing's is cortisol on afterburners.   Cortisol wastes nutrients and nutrients not prescription drugs keep our system in tact.

I have never put all the studies (and my personal experiences with these therapies) down on paper, so here it is:

Polyphenol Studies: 

Dang, this is an update and prioritized at the top! Why? Because these are powerful medicines. I have spent likely 200+ hours in this study. It is quite a broad topic since there are 8,000 known Polyphenols and these can act on different pathways. The experts tell you to eat your fruits and vegetables, in reality they should be telling you to consume your polyphenols. These are chemicals that are found in plant material with some of the strongest concentrations found in spices and herbs. 

They provide an array of protection which includes antioxidant properties, antimicrobial, anti-inflammatory etc. Next time you hear about red wine, green tea or dark chocolate, you are hearing about polyphenols. Nature has a vast array of other beneficial chemicals. 

Metabolic Pathways:

Another updated study. It is quite important to maintain vital pathways. This is done via nutrients and my favorites; polyphenols.

AMPK

SIRT1 etc.

Keap1

Nrf2

PGC-1 

NEI SuperSystem:

Neurological - Endocrine - Immune

A vital and interactive pathway that has been explored in research articles. This is a dynamic system that obviously interplays within each other. Philosophically thinking, this is really one system but medically is considered separate. The premise is that one system can become dominant and when doing so crowds out the other systems. For instance, emotional stressors will trigger cortisol systems (endocrine)which then sets off a domino effect. Cortisol will impact immunity quite negatively, cortisol also attacks the neurological system.

It can work in other ways, for instance a viral infection takes hold which of course triggers immunity, the immune system will call out for support from the endocrine system, the immune system produces byproducts such as cytokines which can pass the blood-brain barrier and impact the neurological. Of course, there are many other examples.

Cell signaling and epigenetics also play a role in this system. The NEI system is one of my favorite studies. 

Oxidative Therapies 
Oxidative Therapies for pathogenic lysing
Oxidative Therapies and enzyme activation
Oxidative Therapies and oxygen donation
Mechanics of Ozone therapy
Ozone Applications (self-administered)
     insufflation techniques
     dosage dependent on antioxidant status
     usage of chelators following mobilization of toxins
       following ozone therapies
Mobilization of toxins in the ozone environment
Redox importance
Setup of equipment
Antioxidants and ozone therapies
H202 therapies (I.V.)
Sodium chlorite as an oxidative therapy

Intracellular Antioxidant Studies 
Glutathione as the master antioxidant
Glutathione wasting conditions
 LIposomal delivery systems
Glutathione and liver
Glutathione and methylation
Thiols and gsh
Cysteine metabolism
Peptide bonding
Superoxide Dismutase
Catalase
Methylation

Oxidation and Redox principles
Antioxidant Studies
Inflammatory immune responses and antioxidants
Oxidation and degenerative diseases
Antioxidant Types
Polyphenols
Herbal preparations for antioxidant

Detoxification Methodology 
Use of specific antioxidants to enhance mobility of toxins
Cellular membrane protection
pH balancing and use of Ionic minerals
Value of electrolytes and detoxification
Zeolites
Clays
Charcoal
EDTA strategies
Liver involvement in detoxification
(I have perfected detoxification approaches which come from several streams and now realize how critical it is to remove the dangerous chemicals not only from the body but from the environment. Without detoxifying then it is much more difficult for the body to recover. Toxins interfere with Krebs Cycles which limits the body's responses)


Gastrointestinal
Probiotic species
SCFA production
Symbiosis
Immunity in the gut
Leaky gut syndrome
Testing
PCR analysis
Benefiical e coli
Probiotics
SIBO
Inflammatory immune responses
Vitamin A and D in mucousal  health
Colostrum and Gastrointestinal health

Liver
Methylation/liver
Herbal preparations for liver health
Phosphatidylcholine
Acupuncture Meridian (liver)

Amino acid therapies
 Thiol groups
 Co-factor involvement
 Glutamate receptors
  Amino Acid Agonists/Antagonists

Minerals and health
  Endocrine involvement and mineralization
  Mineral agonists and antagonists
  Glandular influence on endocrine status
  Co-Factors and mineralization
  Toxic metals and mineralization
  Cardiovascular and minerals
   Immunity and minerals
  Neurochemical aspects of minerals
  Mineral excretion and utilization
  Electrolyte needs in adrenal fatigue
  Sodium/Potassium agonism
  Magnesium in regulation of sodium and potassium
  Copper toxicity
  Zinc/copper interactions
  Selenium and health
  Metabolic typing based on calcium/phosphorous relationships
  Adrenal stress as marked by sodium/potassium and magnesium stores


Vitamin D 
Serum testing of Vitamin d
Vitamin D and magnesium metabolism
Vitamin D and immune responses
vitamin D and neurological conditions
Vitamin D and calcium metabolism


Magnesium
Endocrine involvement in magnesium metabolism
 Kidney uptake and magnesium
Aldosterone involvement in magnesium
Magnesium and adrenal stress
Magnesium and nk cells
Magnesium and vitamin d
Magnesium and cardiovascular
Magnesium and calcium
Magnesium in hbp
Magnesium in the role of ME/CFS
Magnesium and oncogenesis
Magnesium retention and antioxidant status
Magnesium in enzymatic functioning
Magnesium and cns health
Dietary considerations in magnesium uptake
Nutrient interactions in magnesium metabolism
Magnesium and the role of electrolytes
Magnesium and the role of glutathione production


Environmental toxins
Fluoride a super oxidant
Fluoride politics and history
Fluoride and oxidation
Fluoride and magnesium bonding
Pesticide/herbicide
Oxidation techniques for removal of environmental toxins


Toxic Metals
Mercury and immune involvement
Mercury and environmental exposures
Mercury and silver fillings
Mercury mobilization
Detoxification methods of mercury
Detoxification methods of other metals
Glutathione and mercury
Effective chelation therapies (Pharma)
Effective chelation therapies (non-pharma)
Other metals origins and implications in health
Lead, aluminium and other toxic metals
Ozone and its use in removing toxins
Hepatic involvement in toxin removal
Conjugation (phase 2) of Hepatic
Oxidative and neurotoxin properties of mercury
Mercury and thiol group inhibition
Toxic metals and glutathione stores
Mineralization and toxic metals
Toxic metals and chemotheraputic therapies
Toxic metal mobilization using natural substances
 Hepatic involvement in heavy metal detoxification
 Fatty acids and detoxification


Myalgic Encephalomyelitis (Chronic Fatigue Syndrome)
Etiology of ME/CFS
Viral implications in ME/CFS
ME/CFS and adrenal health
ME/CFS and neurological implications
Herpes family - Cytomegalovirus -HHV6
Simian virus
Yeast and fungal issues in ME/CFS
Immune involvement in ME/CFS
Endocrine status in ME/CFS
Cellular immune responses
th1/th2 shifting
th1/th2 and endocrine involvement
HPA- axis dysregulation
HPG axis dysregulation
Glutamate receptors
Neurological implications of ME/CFS
Hippocampus involvement in ME/CFS patients
Infectious etiologies in ME/CFS
Vitamin d status in ME/CFS patients
Essential Fatty acids in ME
Cellular membranes and PC
Oxidative damage in the cellular membrane
Pathogenic involvement in ME
Mycoplasma studies
Yeast/Fungal studies
Gastrointestinal immune responses
Protozoa Studies
Nematode/Cestode Studies
Dysbiosis and probiotics
SCFA production in the Gastrointestinal environment
Oxidative damage by immune reactions
Oxidative consequences by environmental toxins
Cellular membrane Studies
Cellular membrane and oxidation
Cellular membrane and repair phosphatidylcholine
Low dose Naltrexone
Methylation and liver health
Amino Acids in Methylation
Co-factors in Methylation


Mental/Neurological aspects of ME 
Gut/Brain Axis
Cytokine involvement in neurological
Hippocampus
Hypothalamus/pituitary involvment
Endocrine disturbances in ME/CFS
Oxidative stress effects on Neurological
Nutrient interactions in ME conditions
Toxic metal accumulations in immune disorders

Immune responses
Humoral Immunity
Cellular Immunity
Innate Immune responses
Defensins
Antimicrobial peptides
Adrenal involvement of amp
Nutritional implications on immune
Cysteine and its role in Immunity
Vitamin D
Magnesium
Antioxidants
Colostrum
Stealth infections and antigen masking
Opportunistic infections (co infections)
Viral

Biofilm Environments
The mechanics of biofilms
Pleomorphism in the biofilm environment
Immune responses in the biofilm environment
Deep research into disabling biofilms using different substances
Pathogenic implications of biofilms
Biofilms a misunderstood malady
Chronic infections in the biofilm
Biofilm defense mechanisms
Efflux Pumps
Quorum sensing
Quorum sensing and the use of phytonutrients to disable

Antimicrobial resistance

Cellular mechanisms for resistance

Efflux Superfamilies

Phage Therapy

Use of Plant Antimicrobials

Differentiation of Gram Negative vs

  Gram Positive

Physical Observations of resistant patterns

Gu Syndrome

Herbal studies
American Herbalism
Traditional Chinese Medicine
Ayuvedic Medicine
Herbals as medicine
History of herbal medicine
Adaptogens
Polyphenols
CNC degree
Special studies in astringents, blood cleansers, immune enhancement


Essential Fatty acids
Metabolism of fatty acids
Trans Fatty Acids and health implications
Polyphosphatidylcholine and liver health
Polyphosphatidylcholine and cellular membrane health
Omega 3 and 6 Studies


Biochemistry studies 
Methylation Studies
Sulfation
Krebs cycles
Nutrients in Kreb cycle formation
Nutrient interactions in amino acid formation
Endocrine involvement in Metabolism
Vitamin co-factors in biochemical reactions


Protozoa studies
Host defense mechanisms
Protozoa identification
Pharmaceutical intervention
Herbal interventions
Immune defense mechanisms
Endocrine involvement in protozoa infections
The role of protozoa in ME/CFS
The role of protozoa in neurological symptomology
Cytokine involvement
Antimicrobial peptides
Defensins
Innate immune response lactoferrin and lysozyme
sIgA
Antigen shifting
Antimicrobial resistance
Herbal strategies for antimicrobial resistance
Biofilm involvement
Oxidative protectant enzymes
Species (Blastocystis, Cryptosporidium, Giardia)
Dysregulation of host immune response
Dysregulation of Endocrine responses in protozoa infections

Parasite (non-protozoa) studies
Identification
Testing methods
Pharmaceutical intervention in nematode infections
Pharmaceutical intervention in cestode infections
Herbal interventions
Physiological implications of parasitic infections
Host defense systems in parasitic infections
Basic microscopy identification techniques
Basic staining techniques


Endocrine 
Nutrient considerations in Catabolic states
Cushing's
Adenomas
History of Cushings
Morbidity of Cushings
Cushing's as a result of infectious organisms
Thyroid (T3/Rt3/Tsh)
Thymus in Viral conditions
HPA  axis in ME
HPG Axis in infective processes
Endocrine feedback loops
Corticosteroids in Stress reactions
Corticosteroids in Inflammatory conditions
Corticosteroids in Immune system
Androgen involvement in immunity
Mineralcorticoids in stress reactions (Selye)
Metabolic typing in tma
Endocrine influences on metabolism
Endocrine action in immunity
Endocrine interactions agonists/antagonists
Adrenal stress models by Dr. Selye
Adrenal fatigue
Nutrient interactions in adrenal fatigue
Progesterone implications in neurological/immune/endocrine health
Aldosterone production and influence on magnesium metabolism
Parathyroid/thyroid involvement in calcium metabolism
Thyroid involvement in infectious etiologies
DHEA and immunity
DHEA and influence on endocrine systems
Electrolytes in Stage III of adrenal stress


pH
Acidity
Acidity from immune responses
pH balancing
Mineral interaction in pH balancing
Oxidation and pH

Other studies
Liposomal delivery systems
Rife Therapy
EMT Therapy
Magnetism and Health
ERT Therapy
Light therapies
Requirements of UV light spectrums
 Infrared and red spectrums in health (NASA studies)
Homeopathy
Classical Homeopathy
Acupuncture
 Meridians
 TCM applications of herbal remedies
Self administered acupuncture treatments


Other disease studies 
LDN Low Dose Naltrexone
Autism and ME/CFS connections
Cancer
AutoImmune
Neurochemical
Depression/anxiety
Role of toxic metals in schizophrenia
Orthomolecular approaches in mental illness
Lyme disease
Morgellon's disease