Saturday, January 21, 2017

Myalgic Encephalomyelitis (Etiology)


Disclaimer: The material presented is educational and is not meant for treatment or diagnosis. Please consult your healthcare provider before starting any treatment. 

                                            Author: Patrick Bayer C.N.C. - all rights reserved


Some people on a forum devoted to M.E. asked me to summarize both the research and treatment I have accumulated over a course of a long time of research. I estimate that to be around 30k hours in both reading research papers, and my countless hours of observation and treatment. My M.E. had beginnings some 40 years ago and accelerated about 25 years ago. I went through multiple phases of being completely bed ridden to working 15 hours per week. Currently, I am working full time and lead a more functional life. I continue on my core treatments and continue to progress.

M.E. stands for Myalgic Encephalomyelitis which is also known as Chronic Fatigue Syndrome, a recognized set of symptoms by leading authorities including the C.D.C. It is classified as many things including an auto-immune disease. This disease attacks many areas of the body such as the endocrine, immune and neurological. It is perhaps best to explain that the measurable energy output (Krebs Cycle) is low to very low. Energy is a valued and necessary commodity. Energy is needed to perform tasks and these tasks can be many such as work in terms of economic survival to the power necessary to perform the myriad of metabolic functions in the body. Energy is necessary for things to function, this is basic information.

The medical system has largely been unsuccessful in helping those with M.E. which forces patients to seek routes not commonly taken. Sadly, M.E. along with other disabling disease receive little to no funding while the lion's share of research money is given to H.I.V ($34 Billion for 2017). What research has been done is little to no help to those who suffer with this disease. Many M.E. victims also suffer from societal persecution with accusations ranging from mental illness, to lying, to being a coward and a whole host of insensitive and ignorant statements. I find it both sad and disheartening that an "educated" and "civil" society would stoop to such nonsense but stupid is as stupid does. It is a very taxing disease in many ways, many doors are closed and so many obstacles are placed in the way. I made strong decisions to drive around the obstacles and not allow those to stop me in spite of the many refusals to help me.

M.E. has its roots in Western living where chemicals and other short cuts are a normal part of life. Western society has dis-valued others in order to worship at the altars of materialism and power. This leaves its victims in its wake.


M.E. is a multi pronged problem that is rooted in biochemical dysfunction. M.E. is not a behavioral issue, a mental issue or an emotional issue, it is a biological issue unless you reference out-dated and poorly researched information.

Dr. Hooper stated this:
Undoubtedly, the perverse use of CFS, to impose a psychiatric definition for ME/CFS by associating it with fatigue syndromes, has delayed research, the discovery of effective treatment(s), and care and support for those with this illness. (J Clin Pathol. 2007 May; Myalgic encephalomyelitis: a review with emphasis on key findings in biomedical research).

Best selling author, Laura Hillenbrand stated "This illness (M.E.) is to fatigue as a nuclear bomb is to a match -it is an absurd mis characterization".


M.E. is a hyper-complex problem with many potential starting points (etiology). Many theories exist but I think they can be categorized in easy to understand concepts. With this complexity, there is many different etiologies so we cannot assume that what caused a problem for one then the remainder must have this same problem. That is broken logic in my opinion.

M.E. would best be described as being a problem producing energy, this is also known as the Krebs Cycle. Energy production starts at the cellular level which means that it is the cells themselves that produce energy. The hierarchy of the body starts with the cells (lowest level) then migrates to tissues, organs, organ systems and finally the whole organism. There can be a number of factors that disrupt cellular energy in which I will touch on below.

Observations.
Western medicine looks for a single cause, single solution problem whereas Eastern medicine looks at the body as a whole. I will take anxiety for an example. In Western Medicine they would simply say you have anxiety and give a pill for this. In TCM (Traditional Chinese Medicine or Eastern medicine) they might diagnose you with liver stagnation. In the minds of TCM, they would consider liver stagnation to be the causative factor of the anxiety which would be just one of the symptoms of liver stagnation.

So Eastern medicine views the whole system, where one situation can effect the entire body. The idea is that imbalances in the body tilt the whole system, so they try to harmonize the body. TCM largely depends on un-kinking energy blockages (acupuncture or acupressure) and to use botanicals to support the pathways that are blocked. They simply correct the imbalance which makes the system function normally again.


Research Mesearch.
Most of the research is directly towards either the immune system or metabolic pathways that are blocked. One of the key things I have learned about research papers is that the writers of these conceptualize a theory then use supportive evidence to build their case. This could be good or bad. Good in the idea that they are correct in your situation, bad in the respect that this may not be the case  for you. In my opinion, the papers can be shallow in that, yes they have identified the problem and no in that solutions are not provided. No problem can be solved unless it is identified and a plan to unravel the problem.

The problem is that this disease is far too complex to summarize in a single theory. An example of this would be that the etiology of M.E. is due to Epstein Barr virus. This was an early idea and it built strength for sometime until they realized it was not entirely true for all patients.

The clinician needs to make several conclusions first. For many the onset of M.E. started with flu-like symptoms while others developed it without this specific onset. This is a very basic foundational diagnostic in which the first would indicate a strong pathogenic invasion while the second situation may indicate 'softer' issues such as nutrient deficit, a mild viral condition or perhaps a pharmaceutical interaction.

This differentiation would help direct the appropriate treatments. Any strong pathogenic invasion is very problematic and must be addressed. These strong immune reactions change the terrain of the body quite drastically.


Inflammation Model.
The inflammation model is used to describe a myriad of degenerative diseases including M.E. Inflammation is the end result of immune and endocrine activation. Inflammation destroys via oxidative stress. Oxidative stress is the enemy and failure to control it results in cascading downwards. Inflammation can have many starting places, from trauma, infections, poor nutrient quality, emotional stress and so on.

Inflammation puts stress on the body and wastes nutrient stores. If you do not replace the core nutrients then the body cannot repair the damage. Antioxidants repair damage. Antioxidants are naturally produced by the body (glutathione, Superoxide dismutase and catalase) which all depend on raw materials (nutrients) to be produced. Exogenous antioxidants such as Vitamin C and plant based antioxidants help the body to cope with the stress (inflammation).

Oxidative stress attacks the cell membranes. Several research papers have shown the deleterious effects of oxidative stress on the cell membranes. The vitality of the cell membrane is key for proper functioning of the cell and damage reduces the energy output (Krebs Cycle). The cell membrane is largely comprised of healthy fats and is protected by antioxidants.

Where does oxidative stress come from? The three likely sources are from immune activation, environmental toxins and psychological stressors. The immune system is likely elevated in M.E. patients due to pathogenic invasion(s). Oxygen and nitrogen compounds are formed by the immune system and these chemicals are highly damaging.

Nutrient model.
The cells are very dependent on nutrients to do their thing. Every enzyme, protein assimilation, cell/tissue/organ function is dependent on nutrients. Nutrition is largely comprised of minerals, vitamin co-factors, healthy fats and adequate protein (amino acid). Deficiency or excess states will inhibit the proper function of the cells. And remember the cells are the foundations for tissues, organs and so on. The Krebs Cycle (energy) is dependent on nutrients to being robust.

Magnesium is just one of the vital nutrients and deficiency states of this will cause a myriad of problems, such as a dysfunctional immune response, cardiovascular issues, low production of glutathione and enzymes and the list goes on. Dr. Mildred Seelig was a comprehensive researcher of magnesium and wrote many papers that can be found at mgwater.com. One paper she authored was on the role of magnesium and M.E. http://www.mgwater.com/clmd.shtml.

Infectious Organism model.
This is the predominant model that I have worked on. Viral, protozoa, rogue bacteria, parasites  yeast/fungal, unknown or stealth pathogens (l form bacteria, mycoplasma etc).  This means that say one particular virus could be causing the problem. This was an outdated model years ago thinking that Epstein Barr virus was the only culprit. There are a multitude of viral agents that have been identified as a causative factor of M.E.

I had CMV which is in the herpes family, this was a troubling virus for me. Other herpes family viruses such as HHV6, HHV7 etc have been correlated to M.E. and other auto immune diseases. The problem is with testing in that the doctor may have a suspicion of what organism in which they guess. There are many types and subtypes of viral agents that they may not test for and undiscovered ones as well.

Research continues to point in the direction of immune activation as being a culprit in M.E. Most articles reference the T cells being activated. T cells are specific immune cells that are involved protection from pathogens.  With any immune activation then metabolic changes occur which inhibit energy production.

There is an hierarchy in pathogens. This means that some pathogens can lay dormant in the system in which they are symbiotic (do not cause problems) while others can be aggressive which causes a myriad of problems.

The gastrointestinal tract is one area to look for infection and Dr. Leo Galland states this is the first place he looks for infection, particularly parasites. But parasites are not the only problem in the gut, rogue bacteria can harbor the gut as well.

The microbiome is the community of all the organisms living in the gut which provide more support to the body than ever thought. Most of the immune system (70%) is present in the gut. Dr. Galland thinks there is a reason for that in that the GI tract is the most vulnerable to infectious organisms. Fungal and yeast strains can be present there as well along with viral agents.

NEI SuperSystem.
The NEI SuperSystem is one of my favorite studies. The initials stand for Neurological, Endocrine and Immune. These 3 systems are intertwined meaning that they can help one another and conversely negatively affect the others. For instance, constant stress (neurological) will influence the endocrine (adrenal activity) which weakens the immune system. There is a hierarchy in the body and the immune system has the highest priority.

In most cases of M.E., the immune system has the highest gravitational force (assuming that the primary problem is pathogenic). With this strong force then the other systems become subordinate and dysregulated.

Cell Signalling.
Cell signalling is exactly what it says which means there is a complex network of signals in the body. These signals control the body much like a traffic light directs traffic. If there was no traffic signals then chaos would ensue. However the signalling in the body is much more complex than a traffic light since it involves a myriad of processes such as neurotransmitters, hormones, immune signals (cytokines) and much more. Research has shown that each of these classes of signals has the potential of effecting other signalling systems. For instance stress triggers endocrine and the immune system.

The key to taming M.E. is to find the errant signalling system and then the rest should follow, however this is easier said than done. M.E. is like a big traffic jam due to a stalled semi truck that is blocking the intersection, move the truck out of the way and the jam will be fixed. Traditional Chinese Medicine offers a glimpse into this complex world by attempting to balancing the body. Proper nutrition plays a key role in these signalling pathways for without it, the body becomes dysregulated. Without targeted nutrition then the chaos will continue or to worsen.

Neurological.
There have been repeated studies concerning the role of the psychological and the biological systems. Any form of stress triggers the neuro-endocrine system. It is almost impossible to avoid stress in this day and age, it comes at us in many different forms and directions. Trauma, abuse, financial and relationships can be some major stresses along with all the other things that gnaw at us. These events trigger the neurological pathways which in turn stimulate endocrine responses. Cortisol is one of the players in these events which can have deleterious effects after prolonged periods of release. There are known studies which show that cortisol has a negative impact on immune health. Activation of dormant viruses may occur as well as new infections.

One of the bigger omissions in neurological health has to do with the role of the immune system. It is generally accepted that the mind affects the body but the opposite is true: the body can influence the mind. For instance immune activation releases powerful chemicals that change neurological behavior.

Immune Health.
The immune system is comprised of a complex system of different components. Stress, improper diet and nutrient deficiencies can weaken the immune response. A weakened immune response puts us at risk for acquiring new infections or having dormant viruses suddenly reappear.

Endocrine Involvement.
The endocrine system plays key roles in regulation of cycles in the body. It is involved in reproduction, sleep wake cycles, energy production, inflammation and so on. However the endocrine system is involved in immune reactions and the neurological system. Many studies have shown that the HPA axis is deeply involved in M.E. The HPA axis stands for Hypothalamus, Pituitary and Adrenal. There are more aspects of this but I will shorten this and focus on the adrenals. The adrenals are the body's pharmacy, they produce some 50 different hormones. These hormones act on the cells to change their chemistry. One well known hormone is cortisol. Cortisol has many physiological actions, one of them being a natural anti inflammatory.

Continual activation of the adrenals leads to adrenal fatigue. With this draining of the adrenals then the body cannot produce adequate hormone output which then weakens the resistance of the body. A weakened endocrine response also changes neurological and immune function. These three systems (endocrine/immune/neurological) are closely tied to one another and each can influence the others.

Toxin model.
Toxins are poisons. Poisons are poisons because they damage cell function. Toxins come in many shapes and sizes. For instance we are all familar with arsenic, it is a strong poison and can cause serious problems in very small doses but what about the other 800 or so chemicals that are produced?  True, many of them do not have the same effect (potency) as arsenic but what if we are exposed to them day after day for say 20 years. Without proper functioning of the detoxification systems then they can accumulate and damage normal cell functioning.

Some will argue that the body is adept at handling these chemicals but what if the body is damaged? The body has an elaborate set of processes that can handle toxins, take glutathione for one example. Glutathione is a dual acting chemical in which it both supports immune function and assists in detoxification. Production of this chemical can diminish with nutrient deficiency and immune activation.

Other Considerations.
Other studies have shown correlations between auto immunity and vaccinations (ASIA) which is controversial in some circles, however some leading researchers in auto immunity have proven correlation.

Epigenetics (genetics) is a new field of study and researchers are finding correlations with genetics and M.E. A recent study looked at over 9,000 genes and found defects in 16 specific genes that correspond with T cell regulation (immune), neuronal (neurological), mitochondria (energy)* .

(*J Clin Pathol. 2007 May; Myalgic encephalomyelitis: a review with emphasis on key findings in biomedical research)

With epigenetic studies, there has been  proof that supplemental with nutritions/botanicals can improve genetic defects and provide support for weakened metabolic functions in M.E. patients.

I have taken the most commons attributes of the etiology of M.E. and in closing would like to state that if the etiology of one of the above categories may well trip the breakers of the others. For instance, an issue of trauma could set off neurological responses which in turn trigger the endocrine system and with that the immune system becomes disrupted. With this disruption then a viral situation may set foot. Then the immune response will begin an inflammation model which could deplete glutathione stores which then further weaken immune responses and the ability to detoxify.

It is important to target the right areas in order to rebalance the body and they must be done in the correct order. Clinicians must be well versed in all of these areas in order to be effective. The body is an amazing creation and given the right materials, it has the ability to return to a state of balance.

A list of my studies can be found here

M.E. is a complex problem and I found out the hard way that the medical system is not equipped to offer valid help. I can help you make better treatment decisions, I am available for phone consultations at reasonable fees.





Thursday, January 12, 2017

The Good Samaritan

One of my favorite stories is the parable of the Good Samaritan. For those unfamiliar with this parable, Jesus told a story about a Jewish man who had been beaten, robbed and left for dead on the side of the road. He went on to tell the story of how his fellow Jews had passed by the man and it was the "lowly" Samaritan who bound his wounds, took him to the inn and gave him money. The joke of course was that the Samaritans were loathed by the Jewish people.

We can find people who need help everyday. It is our spiritual choice whether we ignore that person or become proactive and do something about that situation  When we have courage and embrace our humanity then the second choice is quite easy, after all people's actions (or lack of actions) define their spirituality.

I talked to one of my disabled friends today and she told me how she has been castigated by her own family because of her illness. When she addressed them about the neglect, they were silent and offered no apology. This is quite a common occurrence among my disabled friends, they are discriminated against because of their disability, a clear form of hatred.

Humans are tri-beings, meaning they are body and mind but also spiritual beings.  Neglect of our spiritual nature is the work of this world we live in today. What does it profit a person if they gain the whole world but lose their souls in the process?




Icelandic Lights



Monday, January 9, 2017

Magnesium

Magnesium is perhaps the most overlooked and important mineral in the body. It is responsible for hundreds of enzymatic functions and without it, the body spirals out of control. Magnesium depletion has been implicated in a number of diseases such as cardiovascular, immune, neurological and endocrine. Cells cannot function properly without magnesium.

Magnesium loss occurs in a number of situations, mostly stress related. Stress can come in a number of forms including emotional, physical, mental and biological stress. Biological stress is perhaps the least understood. Examples of biological stress would include pathogens such as viruses, rogue bacteria, parasitic infections and yeast/fungal infections. Other biological stressors would include environmental toxins and trauma. These events create a hostile environment within the body which reduces magnesium stores.

We derive nutrition from the soil and water. With commercial farming, there can be a depletion of the life giving minerals. Secondly with the processing of foods, we are losing essential nutrients and with additives, we are putting stress on the body to detoxify these chemicals.

Magnesium plays a key role in homeostatis which is a self-governing process in the body. Homeostasis mechanisms allow the body to maintain balances in the body, think of slipping on the ice, the body begins to shift the weight to other side in order to maintain balance so you don't fall.  When we can no longer maintain homeostatis then the body accumulates disease.

All energy comes from the cells, this is known as the Krebs Cycle. The body needs raw materials in order to produce energy, magnesium is one of the most important.

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