After many years of suffering, I finally have a focused idea on what was been plaguing me - Iodamoeba Butschlii an amoebic parasite. This was confirmed by a qualified parasitologist through microscopy. This parasite is considered to be non-pathogenic along with about many others (Entamoeba coli, E. hartmanni, E. polecki, Endolimax nana etc.).
Traditional understanding of this parasite states that it causes no problems in which I developed Cushing's. Cushing's is an overproduction of adrenal hormones traditionally thought to originate from cysts on the adrenals or pituitary glands however it is now understood that the adrenals are stimulated in order to upregulate the immune response. In my case the parasitic infection was so severe that the adrenals reacted very strongly in which I developed Cushings.
Subtypes are genetically different organisms but the same appearing organism when viewed through a microscope. For instance blastocystis hominis is considered to be non-pathogenic but it has been discovered that 11 sub-types are pathogenic, making people ill.
The same holds true for Iodamoeba butschlii in which renowned parasite researcher Dr. Stensvold states:
"Morphologically identical organisms, such as those belonging to Iodamoeba bütschlii, may be found in both human and non-human hosts and may differ genetically across the nuclear small subunit rRNA gene by up to more than 30%! This is quite astonishing given the fact that the difference between human and murine small subunit rDNA is about 1%! Since these data have been established only recently, obviously no one knows the respective clinical significance of these morphologically similar but genetically very different lineages, and further studies may reveal differences in pathogenicity as seen in other amoebic genera. Blastocystis and Entamoeba coli are somewhat similar examples."
Stensvold states in another post that the parasite Blastocystis, that they have collected much data about from the DNA sequencing but for other species such as Iodamoeba, Entamoeba and Endolimax there is very little data available.
He goes on to say that from the little sequencing they have done on Iodamoeba that it has been demonstrated that tremendous genetic variation occurs which represents a complex species rather than 'just' Iodamoeba butschlii. This would indicate that there are sub-types of Iodamoeba that are pathogenic therefore require treatment.
(Stensvold et al, 2012).
Chronic fatigue syndrome, myalgia, pptu, parasite present taxonomy unavailable, Metametrix, GI Effects, myalgic encephalomyelitis